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Combining them doubles GI side effects (nausea, gastroparesis risk) with no additional benefit

GLP-1 agonists indicated for type 2 diabetes 1

doi: 10.1016/j.drudis.2023.103521

Saudi Pharm J 23:487498 Armitage JM, Bowman L, Clarke RJ, Wallendszus K, Bulbulia R, Rahimi K, Haynes R, Parish S, Sleight P, Peto R (2010) Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial

Serious hypersensitivity reactions, including anaphylaxis, laryngeal edema, and bronchospasm have been reported following CARNITOR administration, mostly in patients with end stage renal disease who are undergoing dialysis